See: Multiplexing gRPC and HTTP endpoints with Cloud Run gRPC, Cloud Run & Endpoints ESPv2: Configure Cloud Endpoints to proxy traffic to a Cloud Run multiplexed (gRPC|HTTP) service Challenges: Cloud Run permits single port Cloud Run services publishing e.g. gRPC and Prometheus, must multiplex transports Cloud Run services publishing multiplexed transports are challenging to expose using Cloud Endpoints Hypothesis #1: Multiplexed transports work with Cloud Run See: Multiplexing gRPC and HTTP endpoints with Cloud Run